The Dehorter Lab

The Dehorter Group aims to understand how neurons adapt their activity to the environment and transmit appropriate information to the rest of the neuronal circuits. The team investigates the molecular determinants of that adaptive process that shape and modulate emergent networks in normal conditions, from early stages of brain development to aging. The hypothesis is that common mechanisms exist and contribute to the building or degeneration of the brain. Hence, the lab also examines alterations in key molecular regulators involved in neurodevelopmental and neurodegenerative disorders such as autism and Parkinson’s disease. This research ultimately aims to detect early signs of neuronal dysfunction to restore normal brain activity to alleviate or prevent consequent symptoms. To achieve their goals, The Dehorter lab takes advantage of a multi-disciplinary approach, employing state-of-the-art molecular biology, genetics, in vitro/ in vivo imaging and electrophysiological techniques combined to behavioural assessments.

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The Dehorter lab is based at the Queensland Brain Institute (QBI) at UQ and is affiliated with the John Curtin School of Medical Research (JCSMR) at ANU.